The COVID-19 pandemic has brought with it significant human, social, and economic consequences, some of which are still not yet fully understood. Of course, the continent was already facing significant systemic and structural issues, each of which are affected as a consequence of the pandemic. Responses to these issues therefore need to be structured around and together with post-pandemic planning and recovery. Moreover, Africa faces a range of issues, from the spread of digital technologies and artificial intelligence, a new continent-wide free trade agreement, to burgeoning green and blue economies, that represent both challenges and potential opportunities to further the social and economic development of the continent. This Medium-Term Programme Framework (MTPF) 2022 – 2025, is part of UNECA’s response to the challenge of delivering on the promise of the 2030 and 2063 Agendas. While the response to the COVID-19 pandemic, and measures to deal with the human, societal, and economic costs will likely dominate the agenda over the course of the next few years, the MTPF looks at ways in which the continent can potentially ‘build forward together’, drawing on Africa’s resources, strengths and potential to help drive post-pandemic sustainable development in a transformative way.